Viagra Levitra Cialis – METHOD OF ACTION SIDE EFFECTS

Drug treatments for impotence

Since its introduction in 1998, sildenafil – more widely known under its trade name Viagra – has become one of the most popular drugs on the market. It is the first drug to treat erectile dysfunction (impotence) – a problem that affects more than 30 million. Men in the US alone.

Recently, two other preparation – vardenafil (Levitra) and tadalafil (Cialis) joined sildenafil and forms a class of drugs known as phosphodiesterase inhibitors of type 5 (PDE5). Although there are many other drugs last 2 lead the rankings because they are simple, effective and generally – safe.

What are drugs to treat impotence?

Viagra is a prescription drug that helps men with erectile dysfunction to achieve and maintain an erection. It is usually 1 hour before intercourse. Levitra and Cialis are similar. They differ mainly in the speed and duration of action.

How do they work?

Normal erection is much more complicated than it seems. During sexual arousal, the brain sends signals to the penis via nerves that pass through the spinal cord. These nerves causing a change in the blood vessels, which allow blood to enter, but not to leave the penis. The accumulation of blood in the penis leads to enlargement and hardening. After ejaculation blood vessels in the penis relax, and blood drains out. Any disease or injury that interferes with this process – such as damage to vessels and nerves – can cause erectile dysfunction.

For most men erectile dysfunction is caused by insufficient blood flow to the penis. Inhibitors of PDE5 help, by expanding the blood vessels. They do not cause an erection without sexual / sexual stimulation. After ejaculation penis vavzrashta normal size and condition. Also these drugs have no effect on sexual desire (libido) and do not change the feeling in the penis.

Are effective PDE-inhibitors?

Yes, PDE5-inhibitors are very effective. In some studies, 70% of men have improvement in erectile function after taking one of these medications.

For each person they work?

No. One in three men with mild to severe erectile dysfunction do not respond to Viagra. In some men, not responding to Viagra may be an improvement in Levitra or Cialis. Men with more severe impotence have very little chance to be influenced by these drugs. This also applies if the cause is due to nerve damage – associated with diabetes or certain types of prostate surgery. Many men are affected partly by PDE5-inhibitors and are not reimbursed in full erection

Are effective PDE-5 inhibitors in women?

So far the US Agency for Food and Drug Administration (FDA) has not approved these drugs to be taken by women. Preliminary studies suggest that inhibitors of PDE5 were dangerous in this group, although their effectiveness in the treatment and the treatment of female sexual problems is not clear. Some scientists believe it may effect was observed in women having difficulty with desire or arousal.

Bezopasni are these drugs?
In the first year of the launch of Viagra on the market, FDA has documented the deaths of 130 men who used this drug. Most of these men have died from heart disease. Some of them were taking nitrates (nitroglycerin) – preparations which have severe side effects in combination with Viagra. In other men is not known whether death is associated with Viagra. According to one theory, heart problems are caused more by sexual activity than Viagra itself.
According to many studies, men without heart disease may safely use these drugs. Always remember that PDE5-inhibitors should never be used in combination with nitroglycerin or other nitrates (eg. Isosorbide – izozsorbid). Such a combination can cause severe collapse of blood pressure in otherwise healthy individuals. Be sure to inform your doctor promptly during the examination (especially regarding pain behind the breastbone) if the last 24 hours have used Viagra, Levitra or Cialis. Serious decrease in blood pressure can occur when a combination of PDE-5 inhibitors, alpha-blockers such as tamsulosin (Flomax), doxazosin (Cardura), which predipisvat in trouble with the prostate (benign prostatic hyperplasia). PDE5 inhibitor should also not be taken by men with the following problems:

– A heart attack or stroke within the past 6 months

– Unstable heart disease or heart failure

– Very high or very low blood pressure

– High blood pressure, controlling only through a combination of many drugs

– Liver or kidney disease

– Retinitis pigmentosa (a rare eye disease)

What are the side effects?

PDE5-inhibitors can cause a lot but mild side effects – headache, dizziness, flushing, abnormal vision. As Cialis stays in the body within 48 hours can be observed prolonged painful erection (priapism) in some men.

How to take drugs?

Viagra should be taken on an empty stomach. Required is about 1 hour to act medication. The standard dose is 50 milligrams. Some men achieve good results with 1/2 of the dose, whereas others require a higher dose. The maximum dose should not exceed 100 milligrams. The duration of action was 4 hours.

Levitra is very similar to Viagra speed and duration of action. It can be taken on an empty or full stomach. The standard dose is 10 mg. Some men responded less than 2.5 mlg. It should not be taken more than once a day.

Cialis operate a little faster than the upper two (30 minutes) and the duration of action is up to 36 hours. It should not be taken more than once a day. The standard dose is 10 milligrams.